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研究実績
－2021
Matsui T, Kadono-Maekubo N, Suzuki Y, Furuichi Y, Shiraga K, Sasaki H, Ishida A, Takahashi S, Okada T, Toyooka K, Sharif J, Abe T, Kiyonari H, Tominaga M, Miyawaki A, and Amagai M .
A unique mode of keratinocyte death requires intracellular acidification
Proc Natl Acad Sci. 118 (17) e2020722118
https://pubmed.ncbi.nlm.nih.gov/33893234/
Ouchi T, Morimura S, Dow LE, Miyoshi H, Udey MC.
EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase
Cells. 10 (2): 256, 2021
https://pubmed.ncbi.nlm .nih.gov/33525555/
Aoki S, Hirata Y, Kawai T, Nakabayashi K, Hata K, Suzuki H, Kosaki K, Amagai M, Kubo A. Frequent FGFR3 and Ras Gene Mutations in Skin Tags / Acrochordons
J Invest Dermatol. 2021. Doi: 10.1016 / j. jid.2021.03.028.
https://pubmed.ncbi.nlm.nih.gov/33940034/
－2020
Fusumae T, Fukuda K, Hirai I, Nakamura Y, Tanese K, Iwata T, Funakoshi T.
Outcomes in patients with extramammary Paget disease with brain metastasis: A retrospective analysis
J Am Acad Dermatol. 83(6):1832-1834, 2020
https://pubmed.ncbi.nlm.nih.gov/32450098/
Fujita H, Sasaki T, Miyamoto T, Akutsu SN, Sato S, Mori T, Nakabayashi K, Hata K, Suzuki H, Kosaki K, Matsuura S, Matsubara Y, Amagai M, Kubo A.
Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.
Aging Cell. 19(11):e13251, 2020.
https://pubmed.ncbi.nlm.nih.gov/33094908
－2019
Nakamura Y, Tanese K, Hirai I, Amagai M, Kawakami Y, Funakoshi T.
Serum cytokeratin 19 fragment 21-1 and carcinoembryonic antigen combination assay as a biomarker of tumour progression and treatment response in extramammary Paget disease.
Br J Dermatol. 181(3):535-543, 2019
https://pubmed.ncbi.nlm.nih.gov/30791097/
Someya T and Amagai M.
Toward a new generation of smart skins.
Nat Biotechnol. 37(4), 382-388, 2019.
https://pubmed.ncbi.nlm.nih.gov/30940942/
Kubo A, Sasaki T, Suzuki H, Shiohama A, Aoki S, Sato S, Fujita H, Ono N, Umegaki-Arao N, Kawai T, Nakabayashi K, Hata K, Yamada D, Matsubara Y, Kosaki K, Amagai M.
Clonal expansion of second-hit cells with somatic recombinations or C>T transitions from porokeratosis in MVD or MVK mutant heterozygotes.
J Invest Dermatol. 139(12):2458-2466, 2019
https://pubmed.ncbi.nlm.nih.gov/31207227/
Imaoka M, Tanese K, Masugi Y, Hayashi M, Sakamoto M.
Macrophage migration inhibitory factor-CD74 interaction regulates the expression of programmed cell death ligand 1 in melanoma cells.
Cancer Sci. 110(7):2273-2283, 2019
https://pubmed.ncbi.nlm.nih.gov/31069878/
Hirai I, Tanese K, Nakamura Y, Ishii M, Kawakami Y, Funakoshi T.
Combination cisplatin-epirubicin-paclitaxel therapy for metastatic extramammary Paget’s disease.
The oncologist. 24: e394-e396, 2019.
https://pubmed.ncbi.nlm.nih.gov/30846514/
－2018
Hirai I, Tanese K, Nakamura Y, Otsuka A, Fujisawa Y, Yamamoto Y, Hata H, Fujimura T, Matsushita S, Yoshino K, Kameyama K, Amagai M, Funakoshi T.
Assessment of the methods used to detect HER2-positive advanced extramammary Paget’s disease.
Medical Oncology. 35(6):92, 2018
https://pubmed.ncbi.nlm.nih.gov/29744813/
Nakamura Y, Tanese K, Hirai I, Kameyama K, Kawakami Y, Amagai M, Funakoshi T.
Evaluation of appropriate surgical margin for pigmented basal cell carcinoma according to the risk factor for recurrence: A single-institute retrospective study in Japan
J Eur Acad Dermatol Venereol. 32: e453-e455, 2018.
https://pubmed.ncbi.nlm.nih.gov/29729096/
Yamagami J, Nakamura Y (Co-first author), Nagao K, Funakoshi T, Takahashi H, Tanikawa A, Hachiya T, Yamamoto T, Ishida-Yamamoto A, Tanaka T, Fujimoto N, Nishigori C, Yoshida T, Ishii N, Hashimoto T, Amagai M.
Vancomycin Mediates IgA Autoreactivity in Drug-Induced Linear IgA Bullous Dermatosis.
J Invest Dermatol. 138(7):1473-1480, 2018.
https://pubmed.ncbi.nlm.nih.gov/29410066/
－2017
Baba Y, Funakoshi T, Mori M, Emoto K, Masugi Y, Ekmekcioglu S, Amagai M, Tanese K.
Expression of monoacylglycerol lipase as a marker of tumour invasion and progression in malignant melanoma.
J Eur Acad Dermatol Venereol. 31(12):2038-2045, 2017.
https://pubmed.ncbi.nlm.nih.gov/28681540/
Nakamura Y, Kitano S, Takahashi A, Tsutsumida A, Namikawa K, Tanese K, Abe T, Funakoshi T, Yamamoto N, Amagai M, Yamazaki N.
Nivolumab for advanced melanoma: pretreatment prognostic factors and early outcome markers during therapy.
Oncotarget. 7(47):77404-77415, 2016
https://pubmed.ncbi.nlm.nih.gov/27764805/
Umegaki-Arao N, Sasaki T, Fujita H, Aoki S, Kameyama K, Amagai M, Seishima M, Kubo A. Inflammatory linear verrucous epidermal nevus with a postzygotic GJA1 mutation is a mosaic erythrokeratodermia variabilis et progressiva.
J Invest Dermatol. 137:967-970, 2017.
https://pubmed.ncbi.nlm.nih.gov/27890787/
－2016
Amagai M.
Cracking the code of skin inflammation with CD1a.
Nat Immunol. 17(10):1133-1134, 2016.
https://pubmed.ncbi.nlm.nih.gov/27648537/
Yokouchi M, Atsugi T, Logtestijn MV, Tanaka RJ, Kajimura M, Suematsu M, Furuse M, Amagai M, Kubo A.
Epidermal cell turnover across tight junctions based on Kelvin’s tetrakaidecahedron cell shape.
eLife 5 e19593, 2016.
https://pubmed.ncbi.nlm.nih.gov/27894419/
Amagai M.
Modulating immunity to treat autoimmune disease.
New Eng J Med, 375(15):1487-1489, 2016.
https://pubmed.ncbi.nlm.nih.gov/27732810/
Ouchi T, Nakato G, Udey MC.
EpCAM Expressed by Murine Epidermal Langerhans Cells Modulates Immunization to an Epicutaneously Applied Protein Antigen.
J Invest Dermatol 136:1627-1635, 2016
https://pubmed.ncbi.nlm.nih.gov/27106675/
Ouchi T, Ishii K, Nishikawa T, Ishiko A.
Acquired dermal melanocytosis of the face and extremities.
Clin Exp Dermatol 41:643-647, 2016
https://pubmed.ncbi.nlm.nih.gov/27338120/
－2015
Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, Saya H, Amagai M, Nagao K.
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.
Nat Med, 21(11):1272-1279, 2015.
https://pubmed.ncbi.nlm.nih.gov/26479922/
Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan DH, Kong HH, Amagai M, Nagao K.
Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis.
Immunity, 42(4):756-766, 2015.
https://pubmed.ncbi.nlm.nih.gov/25902485/
Tanese K, Hashimoto Y, Berkova Z, Wang Y, Samaniegp F, Lee JE, Ekmekcioglu S, Grimm EA.
Cell Surface CD74-MIF Interactions Drive Melanoma Survival in Response to Interferon-γ.
J Invest Dermatol. 135(11)2775-2784, 2015.
https://pubmed.ncbi.nlm.nih.gov/26039541/
Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H.
Periostin Is a Key Niche Component for Wound Metastasis of Melanoma.
PLoS One. 10(6):e0129704, 2015
https://pubmed.ncbi.nlm.nih.gov/26083413/
Saito M, Ohyama M, Amagai M.
Exploring the biology of the nail: An intriguing but less-investigated skin appendage.
J Dermatol Sci. 79(3):187-193, 2015
https://pubmed.ncbi.nlm.nih.gov/25999148/
Yokouchi M, Kubo A, Kawasaki H, Yoshida K, Ishii K, Furuse M, Amagai M.
Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum.
J Dermatol Sci. 77:28-36, 2015.
https://pubmed.ncbi.nlm.nih.gov/25511077
－2014
Yoshida K, Kubo A, Fujita H, Yokouchi M, Ishii K, Kawasaki H, Nomura T, Shimizu H, Kouyama K, Ebihara T, Nagao K, Amagai M
Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis
J Allergy Clin Immunol. 134(4):856-864, 2014.
https://pubmed.ncbi.nlm.nih.gov/25282566/
Stahley SN, Saito M, Faundez V, Koval M, Mattheyses AL, Kowalczyk AP.
Desmosome assembly and disassembly are membrane raft-dependent.
PLoS One. 9 (1): e87809, 2014
https://pubmed.ncbi.nlm.nih.gov/24498201/
－2013
Kubo A, Shiohama A, Sasaki T, Nakabayashi K, Kawasaki H, Atsugi T, Sato S, Shimizu A, Mikami S, Tanizaki H, Uchiyama M, Maeda T, Ito T, Sakabe J, Heike T, Okuyama T, Kosaki R, Kosaki K, Kudoh J, Hata K, Umezawa A, Tokura Y, Ishiko A, Niizeki H, Kabashima K, Mitsuhashi Y, Amagai M.
Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis
Am J Hum Genet. 93(5):945-956, 2013.
https://pubmed.ncbi.nlm.nih.gov/24207119/
Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M
A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis
J Allergy Clin Immunol. 132(5):1111-1120, 2013.
https://pubmed.ncbi.nlm.nih.gov/24060273/
Nishimoto S, Kotani H, Tsuruta S, Shimizu N, Ito M, Shichita T, Morita R, Takahashi H, Amagai M, Yoshimura A
Th17 Cells Carrying TCR Recognizing Epidermal Autoantigen Induce Psoriasis-like Skin Inflammation
J Immunol. 191(6):3065-3072, 2013.
https://pubmed.ncbi.nlm.nih.gov/23956432/
Hata T, Nishimoto S, Nagao K, Takahashi H, Yoshida K, Ohyama M, Yamada T, Asano K, Amagai M
Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus
J Immunol. 191(1):83-90, 2013.
https://pubmed.ncbi.nlm.nih.gov/23729442/
Honda R, Cerroni L, Tanikawa A, Ebihara T, Amagai M, Ishiko A
Cutaneous plasmacytosis: Report of 6 cases with or without systemic involvement
J Am Acad Dermatol. 68(6):978-985, 2013.
https://pubmed.ncbi.nlm.nih.gov/23360866/
Veraitch O, Kobayashi T, Imaizumi Y, Akamatsu W, Sasaki T, Yamanaka S, Amagai M, Okano H, Ohyama M
Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo
J Invest Dermatol. 133(6):1479-1488, 2013.
https://pubmed.ncbi.nlm.nih.gov/23321923/
Kubo A, Ishizaki I, Kubo A, Kawasaki H, Nagao K, Ohashi Y, Amagai M
The stratum corneum comprises three layers with distinct metal-ion barrier properties
Sci Rep. 3:1731, 2013.
https://pubmed.ncbi.nlm.nih.gov/23615774/
Yoshida K, Yokouchi M, Nagao K, Ishii K, Amagai M, Kubo A.
Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis.
J Dermatol Sci. 71(2):89-99, 2013.
https://pubmed.ncbi.nlm.nih.gov/23712060/
－2012
Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M.
Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.
Nat Immunol. 13(8):744-752, 2012.
https://pubmed.ncbi.nlm.nih.gov/22729248/
Nagao K, Kobayashi T, Ohyama M, Akiyama H, Horiuchi K, Amagai M.
Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment.
Stem Cells. 30(8):1781-1785, 2012.
https://pubmed.ncbi.nlm.nih.gov/22696231/
Ohyama M, Kobayashi T, Sasaki T, Shimizu A, Amagai M.
Restoration of the intrinsic properties of human dermal papilla in vitro.
J Cell Sci. 125(17):4114-4125, 2012.
https://pubmed.ncbi.nlm.nih.gov/22623722/
Kawasaki H, Nagao K, Kubo A, Hata T, Shimizu A, Mizuno H, Yamada T, Amagai M.
Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice.
J Allergy Clin Immunol. 129(6):1538-1546, 2012.
https://pubmed.ncbi.nlm.nih.gov/22409988/
Saleh MA, Ishii K, Yamagami J, Shirakata Y, Hashimoto K, Amagai M.
Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display.
J Invest Dermatol. 132(4):1141-1148, 2012.
https://pubmed.ncbi.nlm.nih.gov/22277944/
Kubo A, Nagao K, Amagai M.
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases.
J Clin Invest. 122(2):440-447,2012.
https://pubmed.ncbi.nlm.nih.gov/22293182/
Hayato Takahashi, Tomohiko Kanno, Shingo Nakayamada, Kiyoshi Hirahara, Giuseppe Sciume, Stefan A Muljo, Stefan Kuchen, Rafael Casellas, Lai Wei, Yuka Kanno & John J O’Shea.
TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Nat Immunol. 2012 Apr 29;13(6):587-95
https://pubmed.ncbi.nlm.nih.gov/22544395/
Funakoshi T, Lunardon L, Ellebrecht CT, Nagler AR, O’Leary CE, Payne AS.
Enrichment of total serum IgG4 in patients with pemphigus.
Br J Dermatol. 167(6):1245-53, 2012
https://pubmed.ncbi.nlm.nih.gov/22803659/
Saito M, Stahley SN, Caughman CY, Mao X, Tucker DK, Payne AS, Amagai M, Kowalczyk AP.
Signaling dependent and independent mechanisms in pemphigus vulgaris blister formation.
PLoS One. 7(12):e50696, 2012
https://pubmed.ncbi.nlm.nih.gov/23226536/
Saito M, Tucker DK, Kohlhorst D, Niessen CM, Kowalczyk AP.
Classical and desmosomal cadherins at a glance.
J Cell Sci. 125: 2547-52, 2012
https://pubmed.ncbi.nlm.nih.gov/22833291/
－2011
Wada N, Nishifuji K, Yamada T, Kudoh J, Shimizu N, Matsumoto M, Peltonen L, Nagafuchi S, Amagai M.
Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance.
J Invest Dermatol. 131(2):410-417, 2011.
https://pubmed.ncbi.nlm.nih.gov/21048786/
Tsunoda K, Ota T, Saito M, Hata T, Shimizu A, Ishiko A, Yamada T, Nakagawa T, Kowalczyk AP, Amagai M.
Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris.
Am J Pathol. 179(2):795-806, 2011.
https://pubmed.ncbi.nlm.nih.gov/21718682/
Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, Iwakura Y, Yoshimura A, Yamada T,
Kuwana M, Fujii H, Koyasu S, Amagai M.
Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice.
J Clin Invest. 121(9):3677-3688, 2011.
https://pubmed.ncbi.nlm.nih.gov/21821914/
Saleh MA, Ishii K, Kim YJ, Murakami A, Ishii N, Hashimoto T, Schmidt E, Zillikens D, Shirakata Y, Hashimoto K, Kitajima Y, Amagai M Development of NC1 and NC2 domains of type VII collagen ELISA for the diagnosis and analysis of the time course of epidermolysis bullosa acquisita patients.
J Dermatol Sci 62(3):169-175, 2011.
https://pubmed.ncbi.nlm.nih.gov/21482078/
Ouchi T, Kubo A, Yokouchi M, Adachi T, Kobayashi T, Kitashima DY, Fujii H, Clausen BE, Koyasu S, Amagai M, Nagao K.
Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome.
J Exp Med. 208(13):2607-2613, 2011.
https://pubmed.ncbi.nlm.nih.gov/22143886/
Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, Tanahashi S, Ichinose S, Imoto I, Inazawa J, Kudoh J, Amagai M.
SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing.
EMBO Mol. 3(6):320-33, 2011.
https://pubmed.ncbi.nlm.nih.gov/21542132/
Hata T, Nishifuji K, Shimoda K, Sasaki T, Yamada T, Nishikawa T, Koyasu S, Amagai M.
Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris.
J Dermatol Sci. 63(1):33-9, 2011.
https://pubmed.ncbi.nlm.nih.gov/21602032/
－2010
Nishifuji K, Shimizu A, Ishiko A, Iwasaki T, Amagai M
Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation.
J Dermatol Sci. 59(3):184-191, 2010.
https://pubmed.ncbi.nlm.nih.gov/20728315/
Kobayashi T, Iwasaki T, Amagai M, Ohyama M
Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells
J Invest Drmatol. 130(8):1988-95, 2010.
https://pubmed.ncbi.nlm.nih.gov/20357816/
Chan PT, Ohyama B, Nishifuji K, Yoshida K, Ishii K , Hashimoto T, Amagai M.
Immune response towards the amino-terminus of desmoglein 1 prevails across different activity
stages in nonendemic pemphigus foliaceus
Br J Dermatol.162(6):1242-1250, 2010.
https://pubmed.ncbi.nlm.nih.gov/20163417/
－2009
Kubo A, Nagao K, Yokouchi M, Sasaki H, Amagai M.
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers.
J Exp Med. 206(13):2937-2946, 2009.
https://pubmed.ncbi.nlm.nih.gov/19995951/
Saito H, Shimizu A, Tsunoda K, Amagai M, Ishiko A Subcellular localization of desmosomal components is different between desmoglein3 knockout mice and pemphigus vulgaris model mice.
J Dermatol Sci. 55(2):108-115, 2009.
https://pubmed.ncbi.nlm.nih.gov/19525093/
Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP, Mangan NE, Callanan JJ, Kawasaki H, Shiohama A, Kubo A, Sundberg JP, Presland RB, Fleckman P, Shimizu N, Kudoh J, Irvine AD, Amagai M, McLean WH.
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.
Nat Genet. 41(5):602-628, 2009.
https://pubmed.ncbi.nlm.nih.gov/19349982/
Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K, Aiba S, Kaneko F, Izaki S, Tamaki K, Ikezawa Z, Takigawa M, Seishima M, Tanaka T, Miyachi Y, Katayama I, Horiguchi Y, Miyagawa S, Furukawa F, Iwatsuki K, Hide M, Tokura Y, Furue M, Hashimoto T, Ihn H, Fujiwara S, Nishikawa T, Ogawa H, Kitajima Y, Hashimoto K
A randomized double-blind trial of intravenous immunoglobulin for pemphigus.
J Am Acad Dermatol. 60(4):595-603, 2009.
https://pubmed.ncbi.nlm.nih.gov/19293008/
Yokouchi M, Saleh MA, Kuroda K, Hachiya T, Stanley JR, Amagai M, Ishii K.
Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence.
J Invest Dermatol. 129(9):2156-2166, 2009.
https://pubmed.ncbi.nlm.nih.gov/19340014/
Takae Y, Nishikawa T, Amagai M.
Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies.
Exp Dermatol. 18(3):252-260, 2009.
https://pubmed.ncbi.nlm.nih.gov/18643850/
Takahashi H, Kuwana M, Amagai M.
A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris.
J Immunol. 182(3):1740-1745, 2009.
https://pubmed.ncbi.nlm.nih.gov/19155523/
Wang W, Amagai M, Ishiko A.
Desmosome splitting is a primary ultrastructural change in the acantholysis of pemphigus.
J Dermatol Sci. 54(1):59-61, 2009.
https://pubmed.ncbi.nlm.nih.gov/19097754/
Chan PT, Ishiko A, Wada N, Yamamoto N, Amagai M.
Inflammatory plaque with peripheral nodules: a new specific finding of cutaneous polyarteritis nodosa.
J Am Acad Dermatol. 60(2):320-325, 2009.
https://pubmed.ncbi.nlm.nih.gov/19150276/
Tanese K, Fukuma M, Yamada Y, Mori T, Yoshikawa T, Watanabe W, Ishiko A, Amagai M, Nishikawa T, Sakamoto M.
G-protein – coupled receptor GPR49 is up – regulated in nasal cell carcinoma and promotes cell proliferation and tumor formation.
Am J pathol. 173(3):835-843, 2008.
https://pubmed.ncbi.nlm.nih.gov/18688030/
Kubo A, Nagao K, Yokouchi M, Sasaki H, Amagai M.
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers.
J Exp Med. 206:2937-2946, 2009.
https://pubmed.ncbi.nlm.nih.gov/19995951
－2008
Kubo A, Yuba-Kubo A, Tsukita S, Tsukita S, Amagai M.
Sentan: a novel specific component of the apical structure of vertebrate motile cilia Mol Biol Cell. 19(12):5338-5346, 2008.
https://pubmed.ncbi.nlm.nih.gov/18829862/
Takahashi H, Amagai M, Nishikawa T, Fujii Y, Kawakami Y, Kuwana M.
Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris.
J Immunol. 181(2):1526-1535, 2008.
https://pubmed.ncbi.nlm.nih.gov/18606708/
Ota T, Aoki-Ota M, Tsunoda K, Nishikawa T, Koyasu S, Amagai M.
Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance.
Int Immunol. 20(10):1351-360, 2008.
https://pubmed.ncbi.nlm.nih.gov/18765425/
Nagasaka T, Fujii Y, Ishida A, Handa M, Tanikawa A, Amagai M, Nishikawa T.
Evaluating efficacy of plasmapheresis for patients with pemphigus using desmoglein enzyme-linked immunosorbent assay.
Br J Dermatol. 158(4):685-690, 2008.
https://pubmed.ncbi.nlm.nih.gov/18241273/
Saito M, Masunaga T, Teraki Y, Takamori K, Ishiko A.
Genotype-phenotype correlations in six Japanese patients with recessive dystrophic epidermolysis bullosa with the recurrent p.Glu2857X mutation.
J Dermatol Sci. 52(1):13-20, 2008.
https://pubmed.ncbi.nlm.nih.gov/18440202/
－2007
Ohyama M, Vogel JC, Amagai M.
Gene ontology analysis of human hair follicle bulge molecular signature.
J Dermatol Sci. 45(2):147-150, 2007.
https://pubmed.ncbi.nlm.nih.gov/17071058/
－2006
Stanley JR, Amagai M.
Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.
N Engl J Med. 355(17):1800-1810, 2006.
https://pubmed.ncbi.nlm.nih.gov/17065642/
Kawasaki H, Tsunoda K, Hata T, Ishii K, Yamada T, Amagai M.
Synergistic pathogenic effects of combined mouse monoclonal anti-desmoglein 3 IgG antibodies on pemphigus vulgaris blister formation.
J Invest Dermatol. 126(12):2621-2630, 2006.
https://pubmed.ncbi.nlm.nih.gov/16841036/
－2005
Ishii K, Harada R, Matsuo I, Shirakata Y, Hashimoto K, Amagai M.
In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris.
J Invest Dermatol. 124(5):939-946, 2005.
https://pubmed.ncbi.nlm.nih.gov/15854034/
－2004
Nagasaka T, Nishifuji K, Ota T, Whittock NV, Amagai M.
Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome.
J Clin Invest. 114(10):1484-1492, 2004.
https://pubmed.ncbi.nlm.nih.gov/15545999/
－2003
Ota T, Amagai M, Watanabe M, Nishikawa T.
No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases.
J Dermatol Sci. 32(2):137-141, 2003.
https://pubmed.ncbi.nlm.nih.gov/12850306/
Tsunoda K, Ota T, Aoki M, Yamada T, Nagai T, Nakagawa T, Koyasu S, Nishikawa T, Amagai M.
Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3.
J Immunol. 170(4):2170-8, 2003.
https://pubmed.ncbi.nlm.nih.gov/12574390/
Ohyama M, Ota T, Aoki M, Tsunoda K, Harada R, Koyasu S, Nishikawa T, Amagai M.
Suppression of the immune response against exogenous desmoglein 3 in desmoglein 3 knockout mice: an implication for gene therapy.
J Invest Dermatol. 120(4):610-615, 2003.
https://pubmed.ncbi.nlm.nih.gov/12648224/
－2002
Tsunoda K, Ota T, Suzuki H, Ohyama M, Nagai T, Nishikawa T, Amagai M, Koyasu S.
Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.
Eur J Immunol. 32(3):627-633, 2002.
https://pubmed.ncbi.nlm.nih.gov/11857336/
Kobayashi M, Amagai M, Kuroda-Kinoshita K, Hashimoto T, Shirakata Y, Hashimoto K, Nishikawa T.
BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid.
J Dermatol Sci. 30(3):224-232, 2002.
https://pubmed.ncbi.nlm.nih.gov/12443845/
Yamaguchi T, Nishifuji K, Sasaki M, Fudaba Y, Aepfelbacher M, Takata T, Ohara M, Komatsuzawa H, Amagai M, Sugai M.
Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B.
Infect Immun. 70(10):5835-5845, 2002.
https://pubmed.ncbi.nlm.nih.gov/12228315/
Hanakawa Y, Schechter NM, Lin C, Garza L, Li H, Yamaguchi T, Fudaba Y, Nishifuji K, Sugai M, Amagai M, Stanley JR.
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome.
J Clin Invest. 110(1):53-60, 2002.
https://pubmed.ncbi.nlm.nih.gov/12093888/
Ohyama M, Amagai M, Tsunoda K, Ota T, Koyasu S, Hata J, Umezawa A, Nishikawa T.
Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris.
J Invest Dermatol. 118(1):199-204, 2002
https://pubmed.ncbi.nlm.nih.gov/11851895/
Amagai M, Yamaguchi T, Hanakawa Y, Nishifuji K, Sugai M, Stanley JR.
Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1.
J Invest Dermatol. 118(5):845-850, 2002.
https://pubmed.ncbi.nlm.nih.gov/11982763/
－2001
Sekiguchi M, Futei Y, Fujii Y, Iwasaki T, Nishikawa T, Amagai M.
Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins.
J Immunol. 167(9):5439-5448, 2001.
https://pubmed.ncbi.nlm.nih.gov/11673563/
－2000
Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR.
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1.
Nat Med. 6(11):1275-1277, 2000.
https://pubmed.ncbi.nlm.nih.gov/11062541/
Wu H, Wang ZH, Yan A, Lyle S, Fakharzadeh S, Wahl JK, Wheelock MJ, Ishikawa H, Uitto J, Amagai M, Stanley JR.
Protection against pemphigus foliaceus by desmoglein 3 in neonates.
N Engl J Med. 343(1):31-35, 2000.
https://pubmed.ncbi.nlm.nih.gov/10882766/
Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T.
Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus.
J Clin Invest. 105(5):625-631, 2000.
https://pubmed.ncbi.nlm.nih.gov/10712434/
Nishifuji K, Amagai M, Kuwana M, Iwasaki T, Nishikawa T.
Detection of antigen-specific B cells in patients with pemphigus vulgaris by enzyme-linked immunospot assay: requirement of T cell collaboration for autoantibody production.
J Invest Dermatol. 114(1):88-94, 2000.
https://pubmed.ncbi.nlm.nih.gov/10620121/
Proby CM, Ota T, Suzuki H, Koyasu S, Gamou S, Shimizu N, Wahl JK, Wheelock MJ, Nishikawa T, Amagai M.
Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris.
Br J Dermatol. 142(2):321-330, 2000.
https://pubmed.ncbi.nlm.nih.gov/10730768/
－1999
Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR.
Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris.
J Clin Invest. 103(4):461-468, 1999.
https://pubmed.ncbi.nlm.nih.gov/10021453/
Proby C, Fujii Y, Owaribe K, Nishikawa T, Amagai M.
Human autoantibodies against HD1/plectin in paraneoplastic pemphigus.
J Invest Dermatol. 112(2):153-156, 1999.
https://pubmed.ncbi.nlm.nih.gov/9989789/
Amagai M, Komai A, Hashimoto T, Shirakata Y, Hashimoto K, Yamada T, Kitajima Y, Ohya K, Iwanami H, Nishikawa T.
Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus.
Br J Dermatol. 140(2):351-357, 1999.
https://pubmed.ncbi.nlm.nih.gov/10233237/
－1998
Amagai M, Nishikawa T, Nousari HC, Anhalt GJ, Hashimoto T.
Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice.
J Clin Invest. 102(4):775-782, 1998.
https://pubmed.ncbi.nlm.nih.gov/9710446/
－1997
Hashimoto T, Kiyokawa C, Mori O, Miyasato M, Chidgey MA, Garrod DR, Kobayashi Y, Komori K, Ishii K, Amagai M, Nishikawa T.
Human desmocollin 1 (Dsc1) is an autoantigen for the subcorneal pustular dermatosis type of IgA pemphigus.
J Invest Dermatol. 109(2):127-131, 1997.
https://pubmed.ncbi.nlm.nih.gov/9242496/
Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Gamou S, Shimizu N, Nishikawa T.
Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins.
J Immunol. 159(4):2010-2017, 1997.
https://pubmed.ncbi.nlm.nih.gov/9257868/
－1996
Amagai M, Ishii K, Takayanagi A, Nishikawa T, Shimizu N.
Transport to endoplasmic reticulum by signal peptide, but not proteolytic processing, is required for formation of conformational epitopes of pemphigus vulgaris antigen (Dsg3).
J Invest Dermatol. 107(4):539-542, 1996.
https://pubmed.ncbi.nlm.nih.gov/8823357/
Amagai M, Koch PJ, Nishikawa T, Stanley JR.
Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients.
J Invest Dermatol. 106(2):351-355, 1996 https://pubmed.ncbi.nlm.nih.gov/8601740/
－1995
Amagai M, Ishii K, Hashimoto T, Gamou S, Shimizu N, Nishikawa T.
Conformational epitopes of pemphigus antigens (Dsg1 and Dsg3) are calcium dependent and glycosylation independent.
J Invest Dermatol. 105(2):243-247, 1995.
https://pubmed.ncbi.nlm.nih.gov/7543549/
Amagai M, Hashimoto T, Green KJ, Shimizu N, Nishikawa T.
Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus.
J Invest Dermatol. 104(6):895-90, 1995.
https://pubmed.ncbi.nlm.nih.gov/7539469/
－1994
Amagai M, Hashimoto T, Shimizu N, Nishikawa T.
Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus.
J Clin Invest. 94(1):59-67, 1994.
https://pubmed.ncbi.nlm.nih.gov/8040292/
－1993
Tang A, Amagai M, Granger LG, Stanley JR, Udey MC.
Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin.
Nature. 361(6407):82-85, 1993.
https://pubmed.ncbi.nlm.nih.gov/8421498/
－1992
Amagai M, Karpati S, Prussick R, Klaus-Kovtun V, Stanley JR
Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.
J Clin Invest. 90(3):919-926, 1992.
https://pubmed.ncbi.nlm.nih.gov/1522242/
－1991
Amagai M, Klaus-Kovtun V, Stanley JR.
Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.
Cell. 67(5):869-877, 1991.
https://pubmed.ncbi.nlm.nih.gov/1720352/
Amagai M, Elgart GW, Klaus-Kovtun V, Stanley JR.
Southern analysis of the 230-kD bullous pemphigoid antigen gene in normal humans, animals, and patients with junctional epidermolysis bullosa.
J Invest Dermatol. 97(2):249-253, 1991.
https://pubmed.ncbi.nlm.nih.gov/1906508/
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